What do the adrenal glands do?
You have one adrenal gland above each kidney. They produce cortisol, aldosterone and adrenaline — hormones that influence the body's stress response, salt and water balance, and blood pressure.
A lump in an adrenal gland is common and is usually discovered incidentally during a CT scan carried out for another reason. Finding one does not mean cancer and does not mean an operation is needed; it means a structured assessment is needed.
Functioning and non-functioning adrenal lesions
- Non-functioning adrenal adenoma: a benign lesion producing no excess hormone.
- Adrenal incidentaloma: any adrenal mass found unexpectedly on imaging.
- Primary aldosteronism: excess aldosterone, often with high blood pressure and low potassium.
- Cushing syndrome: excess cortisol, which may cause weight gain, high blood pressure and high blood sugar.
- Phaeochromocytoma: a tumour releasing adrenaline-type hormones, causing episodes of high blood pressure, palpitations, sweating and headache.
Hormonal work-up and imaging
- Review of the CT or MRI, including lesion size, density and growth over time.
- Blood pressure, potassium, current medications and symptom review.
- Cortisol testing with a suppression test where indicated.
- Aldosterone-to-renin ratio when there is hypertension or low potassium.
- Plasma or urinary metanephrines to exclude a phaeochromocytoma.
When observation is appropriate
- A small lesion with benign imaging characteristics.
- No hormone excess on biochemical testing.
- No symptoms suggesting a functioning tumour.
- A stable size on repeat imaging over the follow-up period.
When adrenal surgery is considered
Adrenalectomy is discussed when the mass is hormonally active, when it is large or has features on imaging that are not reassuring, when it grows during follow-up, or when a phaeochromocytoma is confirmed.
Where the case is suitable, the operation can often be performed laparoscopically, with small incisions and a quicker recovery. Larger or more complex lesions may require a different surgical approach.
Preparation before surgery and follow-up
Preoperative endocrine preparation is essential rather than routine. In phaeochromocytoma and primary aldosteronism, specific medication is started beforehand to control blood pressure and correct electrolytes, which makes the operation safer.
After surgery, blood pressure and hormone levels are monitored. Depending on the type of lesion, some patients need temporary hormone replacement while the remaining gland recovers.